Mesoporous Properties of Bioactive Glass Synthesized by Spray Pyrolysis with Various Polyethylene Glycol and Acid Additions

Tzu-Yu Peng; Pei-Yun Tsai; May-Show Chen; Yuichi Mine; Shan-Hua Wu; Chin-Yi Chen; Dan-Jae Lin; Chung-Kwei Lin

doi:10.3390/polym13040618

Mesoporous Properties of Bioactive Glass Synthesized by Spray Pyrolysis with Various Polyethylene Glycol and Acid Additions

Polymers (Basel). 2021 Feb 18;13(4):618. doi: 10.3390/polym13040618.

Authors

Tzu-Yu Peng^{1

2

3}, Pei-Yun Tsai^{1

2}, May-Show Chen^{2

4

5}, Yuichi Mine⁶, Shan-Hua Wu⁷, Chin-Yi Chen^{2

7}, Dan-Jae Lin¹, Chung-Kwei Lin^{2

8

9}

Affiliations

¹ School of Dentistry, College of Dentistry, China Medical University, Taichung 404, Taiwan.
² Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
³ Department of Anatomy and Functional Restorations, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
⁴ School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
⁵ Division of Prosthodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan.
⁶ Department of Medical System Engineering, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
⁷ Department of Materials Science and Engineering, Feng Chia University, Taichung 407, Taiwan.
⁸ School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
⁹ Additive Manufacturing Center for Mass Customization Production, National Taipei University of Technology, Taipei 106, Taiwan.

Abstract

Mesoporous bioactive glass (MBG) has a high specific surface area, promoting the reaction area, thereby improving the bioactivity; thus, MBG is currently gaining popularity in the biomaterial field. Spray pyrolysis (SP) is a one-pot process that has the advantages of shorter process time and better particle bioactivity, therefore, MBG was prepared by SP process with various polyethylene glycol (PEG, molecular weight ranged from 2000-12,000) and acid (HCl and CH₃COOH) additions. In vitro bioactivity and mesoporous properties of the so-obtained MBG were investigated. The experimental results showed that all the MBG exhibited amorphous and mesoporous structure. Increasing the molecular weight of PEG can improve the mesoporous structure and bioactivity of MBG. Whereas optimized MBG was prepared with suitable concentration of PEG and CH₃COOH. In the present work, MBG synthesized via spray pyrolysis by adding 5 g of PEG with a molecular weight of 12,000 and 50 mL of CH₃COOH exhibited the best in vitro bioactivity and mesoporous structure.

Keywords: in vitro bioactivity; mesoporous bioactive glass; polyethylene glycol; spray pyrolysis processes.