1 Department of Medicine (Medical Genetics) and Department of Genome Sciences, University of Washington, Seattle, WA 98195-7720, USA. Electronic address: mcking@uw.edu.
This article is based on the address given by the author at the 2020 virtual meeting of The American Society of Human Genetics (ASHG) on October 26, 2020. The video of the original address can be found at the ASHG website.