Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion

Damien Luque Paz; Peter Ashcroft; Radek C Skoda

doi:10.1016/j.stem.2021.02.018

Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion

Cell Stem Cell. 2021 Mar 4;28(3):359-361. doi: 10.1016/j.stem.2021.02.018.

Authors

Damien Luque Paz¹, Peter Ashcroft², Radek C Skoda³

Affiliations

¹ Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Basel, Switzerland.
² Institute of Integrative Biology, ETH Zürich, Zürich, Switzerland.
³ Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: radek.skoda@unibas.ch.

PMID: 33667352
DOI: 10.1016/j.stem.2021.02.018

Abstract

Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations originating from a single hematopoietic stem cell (HSC). In this issue of Cell Stem Cell,Van Egeren et al. (2021) used whole-genome sequencing of hematopoietic colonies to reconstruct the clonal history and time of acquisition of the disease-initiating gene mutation.

Publication types

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MeSH terms

Cell Differentiation
Clone Cells
Hematologic Neoplasms* / genetics
Hematopoietic Stem Cells
Humans
Janus Kinase 2 / genetics
Mutation / genetics
Myeloproliferative Disorders* / genetics

Substances

JAK2 protein, human
Janus Kinase 2