Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking

Biochem Soc Trans. 2021 Apr 30;49(2):893-901. doi: 10.1042/BST20200835.

Abstract

Phosphatidylinositol 3-kinases (PI3Ks) are critical regulators of many cellular processes including cell survival, proliferation, migration, cytoskeletal reorganization, and intracellular vesicular trafficking. They are a family of lipid kinases that phosphorylate membrane phosphoinositide lipids at the 3' position of their inositol rings, and in mammals they are divided into three classes. The role of the class III PI3K Vps34 is well-established, but recent evidence suggests the physiological significance of class II PI3K isoforms in vesicular trafficking. This review focuses on the recently discovered functions of the distinct PI3K-C2α and PI3K-C2β class II PI3K isoforms in clathrin-mediated endocytosis and consequent endosomal signaling, and discusses recently reported data on class II PI3K isoforms in different physiological contexts in comparison with class I and III isoforms.

Keywords: clathrin-mediated endocytosis; endosomal signaling; phosphatidylinositol 3-kinase (PI3K); phosphoinositide; vesicular trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Class II Phosphatidylinositol 3-Kinases / metabolism*
  • Cytoplasmic Vesicles / metabolism*
  • Endocytosis / physiology*
  • Endosomes / metabolism
  • Humans
  • Intracellular Space / metabolism*
  • Isoenzymes / metabolism
  • Signal Transduction / physiology

Substances

  • Isoenzymes
  • Class II Phosphatidylinositol 3-Kinases