Fetal Pulmonary Vein Pulsatility Index in the Third Trimester of Pregnancy as a Predictor of Small for Gestational Age

Abstract

Objective: This study aimed to establish whether the increased fetal pulmonary venous pulsatility index (PVPI) in late pregnancy can independently predict small for gestational age (SGA) and to verify its cut point value and efficacy.

Method: The PVPI was measured in women with singleton pregnancies between 25 and 39 gestational weeks. Maternal hypertension and diabetes, estimated fetal weight (EFW) and percentile of the corresponding weeks of pregnancy (USG_PER), gestational weeks at delivery, and birth weight and percentile of the corresponding weeks of pregnancy (BABY_PER) were reviewed. To assess whether PVPI was independently correlated with BABY_PER, Pearson's correlation analysis was performed. The cut point value of PVPI for the prediction of SGA was established using a receiver operating characteristic (ROC) curve.

Results: A total of 129 mothers were included in this study. Both USG_PER and PVPI were significantly related to SGA, independently (P <.001 and P = .004, respectively). The cut point value of PVPI was found to be 1.13. The AUCs of PVPI and USG_PER were not significantly different (P = .624). The sensitivity of PVPI was 70.27%, and the specificity was 92.39%.

Conclusion: PVPI could predict SGA independently, and the efficacy was comparable to EFW during pregnancy.

Keywords: placental insufficiency; pulmonary venous pulsatility index; small for gestational age.