The protective effect of Indian Catechu methanolic extract against aluminum chloride-induced neurotoxicity, A rodent model of Alzheimer's disease

Ekramy Elmorsy; Eman Elsharkawy; Fahad A Alhumaydhi; Mohamed Salama

doi:10.1016/j.heliyon.2021.e06269

The protective effect of Indian Catechu methanolic extract against aluminum chloride-induced neurotoxicity, A rodent model of Alzheimer's disease

Heliyon. 2021 Feb 14;7(2):e06269. doi: 10.1016/j.heliyon.2021.e06269. eCollection 2021 Feb.

Authors

Ekramy Elmorsy^{1

2}, Eman Elsharkawy^{3

4}, Fahad A Alhumaydhi⁵, Mohamed Salama^{1

6}

Affiliations

¹ Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Egypt.
² Pathology Department, Faculty of Medicine, Northern Border University-ARAR, North Region, Saudi Arabia.
³ Department of Eco Physiology, Ecology and Range Management Division, Desert Research Center, Mathef El-Mataria, 15753 Egypt.
⁴ Department of Chemistry, Science Faculty for Girls, Northern Border University-ARAR, North Region, Saudi Arabia.
⁵ Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia.
⁶ Institute of Global Health and Human Ecology, The American University in Cairo (AUC), Cairo 11385, Egypt.

Abstract

Alzheimer's disease (AD) is the commonest neurodegenerative disorder with a wide array of manifestations, courses, and contributing causes. Despite being clinically characterized a long time ago; no treatment has been developed that could improve the pathology or slow down the disease manifestation- so far. Indian Catechu methanolic extract (ICME) has proved to have multiple beneficial effects that support its use in several disorders- especially those with complex etiology. In the present study, we evaluated the neuroprotective effect of ICME in a rat model of AD using Aluminum Chloride (AlCl3). The results showed that ICME could have a positive impact on the course of AD through its anticholinesterase effect and significant antioxidant effect which was reflected on the animals both on behavioral tests as well as hallmark pathological findings.

Keywords: Acetyl cholinesterase and neuro-monamines; Alzheimer disease; Beta-amyloid proteins; Indian Catechu; Oxidative stress; Tauopathies.