Nuclear Periphery and Telomere Maintenance: TERRA Joins the Stage

Katarína Juríková; Peter De Wulf; Emilio Cusanelli

doi:10.1016/j.tig.2021.02.003

Nuclear Periphery and Telomere Maintenance: TERRA Joins the Stage

Trends Genet. 2021 Jul;37(7):608-611. doi: 10.1016/j.tig.2021.02.003. Epub 2021 Mar 1.

Authors

Katarína Juríková¹, Peter De Wulf², Emilio Cusanelli³

Affiliations

¹ Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy; Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.
² Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.
³ Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy. Electronic address: emilio.cusanelli@unitn.it.

PMID: 33663806
DOI: 10.1016/j.tig.2021.02.003

Abstract

Long noncoding (lnc)RNAs derived from telomeres, the ends of linear eukaryotic chromosomes, help to maintain telomere length and stability by multiple means, including regulation of telomerase activity and recombination-based telomere maintenance. New findings in yeast promote a model in which telomere attachment to the nuclear envelope regulates telomere transcription and maintenance.

Keywords: TERRA; budding yeast; fission yeast; nuclear envelope; telomere; telomeric R-loops.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA-Binding Proteins / genetics
Humans
Nuclear Envelope / genetics*
RNA, Long Noncoding / genetics*
Saccharomyces cerevisiae / genetics
Telomerase / genetics
Telomere / genetics
Telomere Homeostasis / genetics*
Transcription, Genetic*

Substances

DNA-Binding Proteins
RNA, Long Noncoding
Telomerase