Autologous hematopoietic stem cell transplantation in a pediatric patient with aquaporin-4 neuromyelitis optica spectrum disorder

Tuba Rashid Khan; Vincent Zimmern; Victor Aquino; Cynthia Wang

doi:10.1016/j.msard.2021.102852

Autologous hematopoietic stem cell transplantation in a pediatric patient with aquaporin-4 neuromyelitis optica spectrum disorder

Mult Scler Relat Disord. 2021 May:50:102852. doi: 10.1016/j.msard.2021.102852. Epub 2021 Feb 25.

Authors

Tuba Rashid Khan¹, Vincent Zimmern², Victor Aquino³, Cynthia Wang²

Affiliations

¹ Department of Pediatrics, 5323 Harry Hines Blvd. Dallas, Texas 75390, United States; Department of Neurology, 5323 Harry Hines Blvd. Dallas, Texas 75390, United States. Electronic address: tuba.rashidkhan@utsouthwestern.edu.
² Department of Pediatrics, 5323 Harry Hines Blvd. Dallas, Texas 75390, United States; Department of Neurology, 5323 Harry Hines Blvd. Dallas, Texas 75390, United States.
³ Department of Pediatrics, 5323 Harry Hines Blvd. Dallas, Texas 75390, United States; Division of Pediatric Hematology-Oncology, 5323 Harry Hines Blvd. Dallas, Texas 75390, United States.

PMID: 33662857
DOI: 10.1016/j.msard.2021.102852

Abstract

We report on a child with an early and severe manifestation of an Aquaporin-4 (AQP-4) positive Neuromyelitis Optica Spectrum Disorder (NMOSD) who had a refractory disease course despite aggressive immunotherapy and underwent autologous hematopoietic stem cell transplant (AHSCT).

Publication types

Case Reports
Letter

MeSH terms

Aquaporin 4
Autoantibodies
Child
Hematopoietic Stem Cell Transplantation*
Humans
Neuromyelitis Optica* / diagnostic imaging
Neuromyelitis Optica* / therapy
Transplantation, Autologous

Substances

Aquaporin 4
Autoantibodies