Recent advances and controversies in diagnosing and treating male infertility

Rafael F Ambar; Neel Parekh; Ashok Agarwal

doi:10.12703/r/22

Recent advances and controversies in diagnosing and treating male infertility

Fac Rev. 2020 Dec 10:9:22. doi: 10.12703/r/22. eCollection 2020.

Authors

Rafael F Ambar^{1

2

3}, Neel Parekh¹, Ashok Agarwal¹

Affiliations

¹ American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
² Urology Department of Faculdade de Medicina do ABC - FMABC/Andrology Group at Ideia Fertil Institute of Human Reproduction, Santo André, SP, Brazil.
³ Hope Clinic - Fertility Center, Sao Paulo, SP, Brazil.

PMID: 33659954
PMCID: PMC7886078
DOI: 10.12703/r/22

Abstract

Interest in male infertility has increased, as it plays an important role in up to 50% of couples struggling with infertility, which is an estimated 48.5 million couples globally. Despite recent advances, diagnosing and treating male infertility remain a significant clinical challenge owing to complex multifactorial pathways and the diversity of treatment options. This review will assess current controversial topics on male infertility such as the use of home-based semen testing, management of subclinical varicocele, and recent advances in the field of sperm proteomics.

Keywords: Home-based sperm testing; Male Infertility; Proteomics; Sperm DNA fragmentation; Varicocele.

Publication types

Review

Grants and funding

The authors declare that no grants were involved in supporting this work.