The emergence of new concepts and mechanisms for remineralization is of great interest to study. The study objective was to evaluate the clinical efficiency of use of modern remineralizing formulas: "Enamel-sealing liquid" ("Tiefenfluorid", Humanchemie, Germany), "FluoroLux" (TechnoDent, Russia), "InnoDent" (PLC, "InnoDent", Kazakhstan) and ClinproTM XT Varnish (3M ESPE, Germany) in treatment of focal demineralization. According to the number of studied drugs in the framework of a clinical study, four groups of patients with a diagnosis of caries of enamel were formed (n=36): Group 1 (n=9 people, 30 teeth); Group 2 (n=9 people, 29 teeth); Group 3 (n=9 people, 28 teeth); Group 4 (n=9 people, 31 teeth). Evaluation of the clinical efficacy of enamel caries treatment was carried out using 1) vital staining with a 2% aqueous solution of methylene blue followed by evaluation using a control gradation 10-point grayscale; 2) laser-fluorescence method using the apparatus "DiagnoDent Pen" (KaVo). Statistical processing of the obtained results was performed using the Wilcoxon and Money-Whitney test. The confidence level was considered at p≤0.05. According to the data of laser fluorescence of enamel and vital staining, the median index with high statistical significance decreased in all groups after 3 months compared with the data before treatment. Thus, all the studied drugs showed remineralizing activity in the elimination of enamel demineralization foci. This study is the basis for the search and development of new remineralizing compounds for the prevention and treatment of focal enamel demineralization.