How to overcome the side effects of tumor immunotherapy

Shang Li; Zhibi Zhang; Wing-Fu Lai; Liao Cui; Xiao Zhu

doi:10.1016/j.biopha.2020.110639

How to overcome the side effects of tumor immunotherapy

Biomed Pharmacother. 2020 Oct:130:110639. doi: 10.1016/j.biopha.2020.110639. Epub 2020 Aug 20.

Authors

Shang Li¹, Zhibi Zhang², Wing-Fu Lai³, Liao Cui⁴, Xiao Zhu⁵

Affiliations

¹ Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524023, China.
² Biomedical Engineering Research Center, Kunming Medical University, Kunming, 650500, China.
³ Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China; School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, 518172, China. Electronic address: rori0610@graduate.hku.hk.
⁴ Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China; The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang, 524023, China. Electronic address: cuiliao@163.com.
⁵ Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524023, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang, 524023, China; The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang, 524023, China. Electronic address: xzhu@gdmu.edu.cn.

PMID: 33658124
DOI: 10.1016/j.biopha.2020.110639

Abstract

The incidence of cancer is increasing year by year. Cancer has become one of the health threats of modern people. Simply relying on the surgery, chemotherapy or radiotherapy, not only the survival rate is not high, but also the quality of life of patients is not much better. Fortunately, the emergence and rapid development of cancer immunotherapy have brought more and more exciting results. However, when scientists think it is possible to overcome cancer, they find that not all cancer patients can benefit from immunotherapy, that is to say, the overall efficiency of immunotherapy is not high. Drug resistance and side effects of immunotherapy cannot be ignored. In order to overcome these difficulties, scientists continue to improve the strategy of immunotherapy and find that combination therapy can effectively reduce the incidence of drug resistance. They also found that by reprogramming tumor blood vessels, activating ferroptosis, utilizing thioredoxin, FATP2 and other substances, the therapeutic effect can be improved and side effects can be alleviated. This article reviews the principles of immunotherapy, new strategies to overcome drug resistance of cancer immunotherapy, and how to improve the efficacy of immunotherapy and reduce side effects.

Keywords: Immunotherapy; New strategies; Resistance; Side effects.

Publication types

Review

MeSH terms

Animals
CD8-Positive T-Lymphocytes
Drug Resistance, Neoplasm / immunology
Humans
Immunologic Factors
Immunotherapy / adverse effects*
Immunotherapy / methods*
Neoplasms / blood supply
Neoplasms / immunology
Neoplasms / therapy*
Neovascularization, Pathologic
Tumor Microenvironment / immunology

Substances

Immunologic Factors