Three undescribed sesquineolignans, Ziziphusmps A-C (1-3) were isolated from the seeds of Ziziphus jujuba. their gross structure was identified by comprehensive spectroscopic analyses. The part relative configurations were determined by the NOESY correlation and coupling constant. All isolates were tested for their cytotoxicity against the hepatocellular carcinoma Hep3B and HepG2 cells. The results indicated that none of them exhibited obvious cytotoxicity against two hepatocellular carcinoma cell lines.
Keywords: Ziziphus jujuba; cytotoxicity; sesquineolignan; structure elucidation.