IL-6 as a Mediator of the Association Between Traditional Risk Factors and Future Myocardial Infarction: A Nested Case-Control Study

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1570-1579. doi: 10.1161/ATVBAHA.120.315793. Epub 2021 Mar 4.

Authors

Mulugeta M Zegeye¹, Jonas S O Andersson², Patrik Wennberg³, Dirk Repsilber¹, Allan Sirsjö¹, Liza U Ljungberg¹

Affiliations

¹ Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Sweden (M.M.Z., D.R., A.S., L.U.L.).
² Skellefteå Research Unit, Department of Public Health and Clinical Medicine (J.S.O.A.), Umeå University, Sweden.
³ Department of Public Health and Clinical Medicine, Family Medicine (P.W.), Umeå University, Sweden.

PMID: 33657883
DOI: 10.1161/ATVBAHA.120.315793

Abstract

[Figure: see text].

Keywords: acute coronary syndrome; atherosclerosis; biomarker; hypertension; smoking.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Biomarkers / blood
Case-Control Studies
Cytokine Receptor gp130 / blood
Female
Heart Disease Risk Factors
Humans
Hypertension / blood
Hypertension / epidemiology
Inflammation Mediators / blood*
Interleukin-6 / blood*
Male
Middle Aged
Myocardial Infarction / blood*
Myocardial Infarction / diagnosis
Myocardial Infarction / epidemiology
Prognosis
Receptors, Interleukin-6 / blood
Registries
Risk Assessment
Smoking / adverse effects
Sweden / epidemiology
Time Factors

Substances

Biomarkers
IL6 protein, human
IL6R protein, human
IL6ST protein, human
Inflammation Mediators
Interleukin-6
Receptors, Interleukin-6
Cytokine Receptor gp130