Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis

Yuan Jiang; Huiyu Liu; Hang Yu; Yang Zhou; Junting Zhang; Wei Xin; Yiying Li; Siyu He; Cui Ma; Xiaodong Zheng; Lixin Zhang; Xijuan Zhao; Bingxiang Wu; Chun Jiang; Daling Zhu

doi:10.1161/ATVBAHA.120.315525

Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1675-1693. doi: 10.1161/ATVBAHA.120.315525. Epub 2021 Mar 4.

Authors

Yuan Jiang^#^{1

2}, Huiyu Liu^#^{1

2}, Hang Yu^{1

2}, Yang Zhou³, Junting Zhang^{1

2}, Wei Xin^{1

2}, Yiying Li^{1

2}, Siyu He^{1

2}, Cui Ma^{1

2}, Xiaodong Zheng^{1

2}, Lixin Zhang², Xijuan Zhao^{1

2}, Bingxiang Wu, Chun Jiang⁴, Daling Zhu^{1

2

5

6}

Affiliations

¹ Central Laboratory of Harbin Medical University, Daqing, China (Y.J., H.L., H.Y., J.Z., W.X., Y.L., S.H., C.M., X. Zheng, L.X., X. Zhao, D.Z.).
² Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, China (Y.J., H.L., H.Y., J.Z., W.X., Y.L., S.H., C.M., X. Zheng, L.Z., X. Zhao, D.Z.).
³ Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, China (Y.Z.).
⁴ Department of Biology, Georgia State University, Atlanta, GA (C.J.).
⁵ State Province Key Laboratories of Biomedicine-Pharmaceutics of China, Daqing (D.Z.).
⁶ Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, China (D.Z.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: fluorescence; hypertension, pulmonary; phenotype; pyroptosis; upregulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis Regulatory Proteins / genetics
Apoptosis Regulatory Proteins / metabolism*
Calcium-Binding Proteins / genetics
Calcium-Binding Proteins / metabolism*
Cells, Cultured
Disease Models, Animal
Hypertension, Pulmonary / genetics
Hypertension, Pulmonary / metabolism*
Hypertension, Pulmonary / pathology
Hypertension, Pulmonary / physiopathology
Male
Mice
Mice, Inbred C57BL
MicroRNAs / genetics
MicroRNAs / metabolism*
Muscle, Smooth, Vascular / metabolism*
Muscle, Smooth, Vascular / pathology
Muscle, Smooth, Vascular / physiopathology
Myocytes, Smooth Muscle / metabolism*
Myocytes, Smooth Muscle / pathology
Pulmonary Artery / metabolism
Pulmonary Artery / pathology
Pulmonary Artery / physiopathology
Pyroptosis*
RNA, Circular / genetics
RNA, Circular / metabolism*
Signal Transduction

Substances

Apoptosis Regulatory Proteins
Calcium-Binding Proteins
MicroRNAs
Mirn124 microRNA, mouse
Pdcd6 protein, mouse
RNA, Circular