CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates Cerebral Cavernous Malformation Through Map3k3-KLF Signaling Pathway

Stroke. 2021 Apr;52(4):1428-1436. doi: 10.1161/STROKEAHA.120.031523. Epub 2021 Mar 4.

Jaesung P Choi^{1

2}, Xi Yang³, Shuang He⁴, Renhua Song⁵, Zi-Ran Xu⁴, Matthew Foley⁶, Justin J-L Wong⁵, Cheng-Ran Xu⁴, Xiangjian Zheng^{1

3}

¹ Lab of Cardiovascular Signaling, Centenary Institute, Sydney Medical School (J.P.C., X.Z.), University of Sydney, NSW, Australia.
² Centre for Inflammation, Centenary Institute, School of Life Sciences, University of Technology Sydney, NSW, Australia (J.P.C.).
³ Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (X.Y., X.Z.).
⁴ Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing, China (S.H., Z.-R.X., C.-R.X.).
⁵ Epigenetics and RNA Biology Program Centenary Institute, Sydney Medical School (R.S., J.J.-L.W.), University of Sydney, NSW, Australia.
⁶ Australian Centre for Microscopy and Microanalysis (M.F.), University of Sydney, NSW, Australia.

Abstract

[Figure: see text].

Keywords: cerebral hemorrhage; endothelial cells; gene expression; mutation; tomography.