Mitochondrial dysfunction defines T cell exhaustion

Gonzalo Soto-Heredero; Gabriela Desdín-Micó; María Mittelbrunn

doi:10.1016/j.cmet.2021.02.010

Mitochondrial dysfunction defines T cell exhaustion

Cell Metab. 2021 Mar 2;33(3):470-472. doi: 10.1016/j.cmet.2021.02.010.

Authors

Gonzalo Soto-Heredero¹, Gabriela Desdín-Micó¹, María Mittelbrunn²

Affiliations

¹ Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
² Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. Electronic address: mmittelbrunn@cbm.csic.es.

PMID: 33657392
DOI: 10.1016/j.cmet.2021.02.010

Abstract

When T cells are exposed to continuous antigen stimulation, they become exhausted. Here, we preview findings from Scharping et al. (2021), who have illuminated the molecular mechanism by which the persistent antigen stimulation and severe hypoxic conditions in the intratumoral environment drive T cell exhaustion, losing their cytotoxic function and anticancer effects.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

CD8-Positive T-Lymphocytes* / metabolism
Mitochondria*