Passing on PCOS: new insights into its epigenetic transmission

David H Abbott; Daniel A Dumesic

doi:10.1016/j.cmet.2021.02.008

Passing on PCOS: new insights into its epigenetic transmission

Cell Metab. 2021 Mar 2;33(3):463-466. doi: 10.1016/j.cmet.2021.02.008.

Authors

David H Abbott¹, Daniel A Dumesic²

Affiliations

¹ Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. Electronic address: abbott@primate.wisc.edu.
² Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Abstract

Polycystic ovary syndrome (PCOS) is a prevalent reproductive-metabolic disorder with poorly understood etiology. Mimouni et al. (2021) demonstrate global genomic DNA hypomethylation in women with PCOS and their daughters, and in F3 generation PCOS-like mice, together with substantial normalization of PCOS-like mice by methyl donor dietary supplementation.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
DNA Methylation
Epigenesis, Genetic
Epigenomics
Female
Humans
Mice
Polycystic Ovary Syndrome* / genetics

Abstract

Publication types

MeSH terms

Grants and funding