Diabetes and COVID-19; a Review of Possible Mechanisms

Reyhaneh Moradi-Marjaneh; Fereshteh Asgharzadeh; Elnaz Khordad; Mahdi Moradi Marjaneh

doi:10.2174/1381612827666210303141846

Diabetes and COVID-19; a Review of Possible Mechanisms

Curr Pharm Des. 2021;27(21):2522-2527. doi: 10.2174/1381612827666210303141846.

Authors

Reyhaneh Moradi-Marjaneh¹, Fereshteh Asgharzadeh², Elnaz Khordad³, Mahdi Moradi Marjaneh⁴

Affiliations

¹ Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
² Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
⁴ Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.

PMID: 33655850
DOI: 10.2174/1381612827666210303141846

Abstract

Coronavirus disease 2019 (SARS-CoV-2) (COVID-19) has recently raised worldwide public health concerns. The available data on COVID-19 in patients with diabetes is limited but generally indicate that there is an increased risk of developing COVID-19 infection in diabetic patients, which ultimately impacts the overall patient's survival. Various aspects might be involved; however, the exact mechanisms and interrelationships between diabetes and the novel COVID-19 have not yet been fully elucidated. This review summarizes the possible mechanisms by which present diabetes predispose individuals to COVID-19 infection, modulates the hostviral interactions and increases the risk of mortality. We hope this review can provide beneficial information for further studies and contribute to improved disease management of diabetic patients with COVID-19.

Keywords: COVID-19; Diabetes; SARS-CoV-2.; mechanism; prognosis; review; risk factor.

Publication types

Review

MeSH terms

COVID-19*
Diabetes Mellitus*
Humans
SARS-CoV-2