Effect of triclosan on the pathogenesis of allergic diseases among children

Min-Hua Lin; She-Yu Chiu; Wen-Chao Ho; Kai-Hsien Chi; Tsung-Yun Liu; I-Jen Wang

doi:10.1038/s41370-021-00304-w

Effect of triclosan on the pathogenesis of allergic diseases among children

J Expo Sci Environ Epidemiol. 2022 Jan;32(1):60-68. doi: 10.1038/s41370-021-00304-w. Epub 2021 Mar 2.

Authors

Min-Hua Lin^#^{1

2}, She-Yu Chiu^#³, Wen-Chao Ho^{4

5}, Kai-Hsien Chi⁶, Tsung-Yun Liu⁶, I-Jen Wang^{7

8

9

10

11}

Affiliations

¹ Department of Nutrition, China Medical University, No.100, Sec.1, Jingmao Road, Beitun Dist, Taichung, 4046040, Taiwan.
² Department of Dietetics, Yunlin Christian Hospital, No.375, Shichang S Road, Xiluo Township, Yunlin, 648102, Taiwan.
³ Institute of Population Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan Township, Miaoli, 35053, Taiwan.
⁴ College of Public Health, China Medical University, No.100, Sec.1, Jingmao Road, Beitun Dist, Taichung, 406040, Taiwan.
⁵ Department of Nursing & Graduate Institute of Nursing, Asia University, No.500, Lioufeng Road, Wufeng, Taichung, 41354, Taiwan.
⁶ School of Medicine, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei, 11221, Taiwan.
⁷ College of Public Health, China Medical University, No.100, Sec.1, Jingmao Road, Beitun Dist, Taichung, 406040, Taiwan. wij636@gmail.com.
⁸ School of Medicine, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei, 11221, Taiwan. wij636@gmail.com.
⁹ Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, 24213, Taiwan. wij636@gmail.com.
¹⁰ National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, 350401, Taiwan. wij636@gmail.com.
¹¹ National Taiwan University, Taipei, 10617, Taiwan. wij636@gmail.com.

^# Contributed equally.

PMID: 33654271
DOI: 10.1038/s41370-021-00304-w

Abstract

Background: Few studies have assessed associations between allergic diseases and antibacterial agents in Taiwanese children.

Objective: This study aimed to investigate the association of triclosan (TCS) exposure with allergic diseases among preschoolers, disease-specific IgE titers, and a child's sex.

Methods: Pediatric data were obtained from the Childhood Environment and Allergic Diseases Study (CEAS; 2010) cohort, and their urine and blood samples were used to analyze TCS and IgE concentrations (age 3 group). Three years later, clinical data were obtained again from the age 3 group (age 6 group). Correlations of TCS levels at ages 3 and 6 years with IgE levels and allergic diseases were evaluated.

Results: The TCS levels were higher at age 3 than at age 6 (geometric mean, 1.05 ng/ml vs 0.37 ng/ml). TCS levels were positively correlated with serum IgE levels at ages 3 and 6 years. Asthma and atopic dermatitis were significantly associated with TCS (adjusted OR 1.14, 95% confidence interval [CI] 1.01-1.29; OR 1.22, 95% CI 1.05-1.41). Sex-stratified analysis revealed that TCS levels were positively correlated with IgE levels among boys in the age 6 group and significantly associated with asthma, allergic rhinitis, and atopic dermatitis among boys.

Significance: TCS exposure is associated with IgE levels and a potentially high risk of pediatric atopic disorders.

Keywords: Allergic diseases; IgE levels; Triclosan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asthma*
Child
Child, Preschool
Dermatitis, Atopic* / chemically induced
Humans
Hypersensitivity*
Immunoglobulin E
Male
Triclosan* / adverse effects

Substances

Immunoglobulin E
Triclosan