Colorectal cancer is the third leading cancer-related fatal disease in the world, and its morbidity and mortality are increasing. In recent years, the researches of miRNAs have provided new ideas for the diagnosis and treatment of colorectal cancer. Although previous studies have confirmed the abnormal expression of miR-483 in different types of tumors, the expression level of miR-483 in colorectal cancer remains to be elucidated. The effect of up-regulated miR-483 on colorectal cancer cell function was detected by cell function test. In order to further clarify the effect of up-regulation of miR-483 on colorectal cancer cells, we carried out tumorigenesis experiments in nude mice. The results showed that after transplantation of colorectal cancer cells subcutaneously in nude mice, the tumors in the over-expression group of miR-483 were significantly larger than those in the control group. miR-483 is an important regulator of the occurrence and development of colorectal cancer. The results of this study are helpful to understand the development of colorectal cancer and to formulate diagnosis and treatment strategies for colorectal cancer.
Keywords: colorectal cancer; miR-483; oncogene.
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