Emerging roles of dehydrogenase/reductase member 2 (DHRS2) in the pathology of disease

Zhenzhen Li; Huiwen Liu; Ann Bode; Xiangjian Luo

doi:10.1016/j.ejphar.2021.173972

Emerging roles of dehydrogenase/reductase member 2 (DHRS2) in the pathology of disease

Eur J Pharmacol. 2021 May 5:898:173972. doi: 10.1016/j.ejphar.2021.173972. Epub 2021 Feb 27.

Authors

Zhenzhen Li¹, Huiwen Liu¹, Ann Bode², Xiangjian Luo³

Affiliations

¹ Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, PR China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, PR China.
² The Hormel Institute, University of Minnesota, Austin, MN, 55912, USA.
³ Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, PR China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, PR China; Molecular Imaging Research Center of Central South University, Changsha, Hunan, 410078, PR China. Electronic address: luocsu@csu.edu.cn.

PMID: 33652058
DOI: 10.1016/j.ejphar.2021.173972

Abstract

Dehydrogenase/reductase member 2 (DHRS2) belongs to the short-chain dehydrogenase/reductase (SDR) family. It was initially isolated from the nuclear extract of hepatocellular carcinoma HepG2 cells and was identified as a specific cell cycle regulator. DHRS2 is a reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent carbonyl reductase and catalyzes the reduction of dicarbonyl compounds. It is also functionally active in lipid metabolism and acts as a metabolic enzyme of hormones. Recent studies have shown that DHRS2 reprograms lipid metabolism and redox homeostasis to regulate proliferation, migration, invasion, and drug resistance of cancer cells. Here, we describe the structure, organelle localization and function of DHRS2, and also highlight its roles in the pathologic progression of diseases.

Keywords: Cancer; DHRS2; Lipid metabolism; SDR.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Carbonyl Reductase (NADPH) / antagonists & inhibitors
Carbonyl Reductase (NADPH) / chemistry
Carbonyl Reductase (NADPH) / metabolism*
Enzyme Inhibitors / pharmacology
Humans
Lipid Metabolism* / drug effects
Neoplasms / drug therapy
Neoplasms / enzymology*
Neoplasms / pathology
Protein Conformation
Structure-Activity Relationship

Substances

Antineoplastic Agents
Enzyme Inhibitors
Carbonyl Reductase (NADPH)
DHRS2 protein, human