Prostate-Specific Membrane Antigen PET for Assessment of Primary and Recurrent Prostate Cancer with Histopathology as Reference Standard: A Systematic Review and Meta-Analysis

Eivor Hernes; Mona-Elisabeth Revheim; Knut Håkon Hole; Andreas Julius Tulipan; Hilde Strømme; Wolfgang Lilleby; Therese Seierstad

doi:10.1016/j.cpet.2020.12.001

Prostate-Specific Membrane Antigen PET for Assessment of Primary and Recurrent Prostate Cancer with Histopathology as Reference Standard: A Systematic Review and Meta-Analysis

PET Clin. 2021 Apr;16(2):147-165. doi: 10.1016/j.cpet.2020.12.001.

Authors

Eivor Hernes¹, Mona-Elisabeth Revheim², Knut Håkon Hole², Andreas Julius Tulipan², Hilde Strømme³, Wolfgang Lilleby⁴, Therese Seierstad⁵

Affiliations

¹ Division of Radiology and Nuclear Medicine, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway. Electronic address: ehh@ous-hf.no.
² Division of Radiology and Nuclear Medicine, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318 Oslo, Norway.
³ Library of Medicine and Science, University of Oslo, Sognsvannsveien 20, 0372 Oslo, Norway.
⁴ Department of Oncology, Oslo University Hospital, P.O. Box 4953 Nydalen, 0424 Oslo, Norway.
⁵ Division of Radiology and Nuclear Medicine, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway.

PMID: 33648661
DOI: 10.1016/j.cpet.2020.12.001

Abstract

Prostate-specific membrane antigen PET is a promising diagnostic tool in prostate cancer. The gold standard for the detection of prostate tumor and lymph node metastases is histopathology. The aim of the present review was to investigate accuracy measures of ⁶⁸Ga/¹⁸F-labeled prostate-specific membrane antigen PET tracers in primary and recurrent prostate cancer with systematic sector-based histopathology as the reference standard. A systematic literature search was performed and 34 studies were included. Overall, prostate-specific membrane antigen PET showed high specificity, but variable sensitivity to localize known prostate cancer and detect pelvic lymph node metastases.

Keywords: Histopathology; Lymph node metastases; PSMA PET; Personalized medicine; Primary tumor location; Prostate cancer.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Humans
Male
Neoplasm Recurrence, Local / diagnostic imaging
Positron Emission Tomography Computed Tomography*
Prostatic Neoplasms* / diagnostic imaging
Reference Standards