Sarcoptes scabiei is an ectoparasite known to infect different species of mammals. Mite is known to infect mankind since antiquity. Current scabicidal agents are becoming less effective due to resistance generated by the mite. The present review focuses on exploration of various herbal and non-herbal/synthetic agents that are proven to be efficient against scabies mite of different mammalian species. In vitro and in vivo acaricidal activities carried out for different dosage forms developed for these scabicidal agents are also discussed.