Abstract
Herein, we report the first use of gluthathione (GSH)-responsive nanogel-based carriers for mitochondria-targeted delivery of functional proteins and antibodies. We further demonstrated the successful co-encapsulation of a protein and small molecule (RNase A/Doxorubicin) in dual-cargo nanocapsules for mitochondria-targeted combination therapy.
MeSH terms
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Antibiotics, Antineoplastic / administration & dosage*
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Doxorubicin / administration & dosage*
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Drug Delivery Systems
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Glutathione / chemistry
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HeLa Cells
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Humans
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Mitochondria / chemistry
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Mitochondria / drug effects*
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Nanocapsules / chemistry*
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Ribonuclease, Pancreatic / administration & dosage*
Substances
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Antibiotics, Antineoplastic
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Nanocapsules
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Doxorubicin
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Ribonuclease, Pancreatic
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Glutathione