Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice

Jing Li; Heng Zhang; Yongqiang Dong; Xian Wang; Guang Wang

doi:10.3389/fphys.2021.628122

Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice

Front Physiol. 2021 Feb 12:12:628122. doi: 10.3389/fphys.2021.628122. eCollection 2021.

Authors

Jing Li¹, Heng Zhang¹, Yongqiang Dong², Xian Wang², Guang Wang¹

Affiliations

¹ Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
² Key Laboratory of Molecular Cardiovascular Science, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Ministry of Education, Peking University, Beijing, China.

Abstract

The adipose Nod-like receptor protein 3 (NLRP3) inflammasome initiates insulin resistance; however, the mechanism of inflammasome activation in adipose tissue remains elusive. In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process. Hcy-induced activation of NLRP3 inflammasomes were observed in adipose tissue during the generation of insulin resistance in vivo. This animal model suggests that diets high in omega-3 fatty acids alter serum and adipose lipid profiles, and in this way, omega-3 fatty acids may reduce adipose tissue inflammation and attenuate insulin resistance.

Keywords: adipocyte; homocysteine; inflammation; insulin resistance; omega-3 fatty acids.