Autophagy as a Vital Therapy Target for Renal Cell Carcinoma

Ying-Hua He; Guo Tian

doi:10.3389/fphar.2020.518225

Autophagy as a Vital Therapy Target for Renal Cell Carcinoma

Front Pharmacol. 2021 Feb 10:11:518225. doi: 10.3389/fphar.2020.518225. eCollection 2020.

Authors

Ying-Hua He¹, Guo Tian²

Affiliations

¹ Department of Clinical Pharmacy, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
² Hepatobiliary and Pancreatic Intervention Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Abstract

Autophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC). Many autophagy-related proteins are regarded as prognostic markers of RCC. Researchers have attempted to explore synthetic and phytochemical drugs for RCC therapy that target autophagy. In this review, we highlight the importance of autophagy in RCC and potential treatments related to autophagy.

Keywords: AMPK/mTOR; PI3K/AKT/mTOR; autophagy; inducers; inhibitor; rcc.

Publication types

Review