Muscle Infiltrative Adult Multisystem Langerhans Cell Histiocytosis Detected on Fluorodeoxyglucose Positron Emission Tomography/ Computed Tomography - A Rare Case

Sampanna Jung Rayamajhi; Rajive Raj Shahi; Sagar Maharjan; Samir Sharma; K C Sudhir Suman

doi:10.4103/ijnm.IJNM_88_20

Muscle Infiltrative Adult Multisystem Langerhans Cell Histiocytosis Detected on Fluorodeoxyglucose Positron Emission Tomography/ Computed Tomography - A Rare Case

Indian J Nucl Med. 2020 Oct-Dec;35(4):342-344. doi: 10.4103/ijnm.IJNM_88_20. Epub 2020 Oct 21.

Authors

Sampanna Jung Rayamajhi¹, Rajive Raj Shahi¹, Sagar Maharjan¹, Samir Sharma², K C Sudhir Suman¹

Affiliations

¹ Kundalini Diagnostic Center, Kathmandu, Nepal.
² Narayani Samudaik Hospital and Research Center, Bharatpur, Chitwan, Nepal.

Abstract

Langerhans cell histiocytosis (LCH) is a disease of unknown pathogenesis characterized by the accumulation of Langerhans cells which show immunopositivity for S-100 and CD1a. LCH with skeletal muscle involvement has been rarely described in literature. ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) is an important tool in identifying the sites of involvement in LCH. We present a rare case of muscle invasive LCH where ¹⁸F-FDG PET/CT showed involvement of multiple other sites such as the liver, bones, bone marrow, and possibly the thyroid gland in our case. Further, the current case also shows that liver involvement by LCH (possibly fibrotic phase) can be negative on PET but show lesions on CT.

Keywords: Fluorodeoxyglucose; Langerhans cell histiocytosis; positron emission tomography.