Advances in asthma genetics

Adv Genet. 2021:107:1-32. doi: 10.1016/bs.adgen.2020.11.001. Epub 2021 Feb 2.

Abstract

While asthma has a strong genetic component, our current ability to systematically understand and predict asthma risk remains low, despite over a hundred genetic associations. The reasons for this unfilled gap range from technical limitations of current approaches to fundamental deficiencies in the way we understand asthma. These are discussed in the context of genomic advances.

Keywords: Airway disease; Asthma; Genetics; Genomics; Microbiome.

Publication types

  • Review

MeSH terms

  • Anti-Asthmatic Agents / pharmacology*
  • Asthma / drug therapy
  • Asthma / genetics*
  • Asthma / microbiology
  • Biomarkers
  • Epigenesis, Genetic*
  • Gene-Environment Interaction
  • Genetic Linkage
  • Genome-Wide Association Study*
  • Humans
  • Lipopolysaccharide Receptors / genetics
  • Lung / microbiology
  • Microbiota / physiology*
  • Pedigree
  • Pharmacogenomic Testing
  • Precision Medicine
  • Transcriptome
  • Twin Studies as Topic

Substances

  • Anti-Asthmatic Agents
  • Biomarkers
  • CD14 protein, human
  • Lipopolysaccharide Receptors