Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II-Induced Hypertension in PT- Agtr1a-/- Mice

Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II-Induced Hypertension in PT- Agtr1a^-/- Mice

Hypertension. 2021 Apr;77(4):1285-1298. doi: 10.1161/HYPERTENSIONAHA.120.16336. Epub 2021 Mar 1.

Xiao Chun Li^{1

2}, Ana Paula Oliveira Leite^{1

2}, Xiaowen Zheng³, Chunling Zhao³, Xu Chen⁴, Liang Zhang^{1

2}, Xinchun Zhou⁵, Isabelle Rubera⁶, Michel Tauc⁶, Jia Long Zhuo^{1

2}

¹ From the Tulane Hypertension and Renal Center of Excellence (X.C.L., A.P.O.L., L.Z., J.L.Z.).
² Department of Physiology, Tulane University School of Medicine, New Orleans, LA (X.C.L., A.P.O.L., L.Z., J.L.Z.).
³ Department of Emergency Medicine, Guangxi Medical University, Nanning, China (X. Zheng, C.Z.).
⁴ Department of Physiology (X.C.), University of Mississippi Medical Center, Jackson.
⁵ Department of Pathology (X. Zhou), University of Mississippi Medical Center, Jackson.
⁶ Université Côte d'Azur, CNRS UMR-7370, Laboratoire de Physiomédecine Moléculaire, Nice, France (I.R., M.T.).

[Figure: see text].

Keywords: angiotensin II; electrolytes; homeostasis; hypertension; natriuresis.