Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment

Tatiana A Mishchenko; Irina V Balalaeva; Maria V Vedunova; Dmitri V Krysko

doi:10.1016/j.trecan.2021.01.013

Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment

Trends Cancer. 2021 Jun;7(6):484-487. doi: 10.1016/j.trecan.2021.01.013. Epub 2021 Feb 25.

Authors

Tatiana A Mishchenko¹, Irina V Balalaeva¹, Maria V Vedunova¹, Dmitri V Krysko²

Affiliations

¹ Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation.
² Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation; Cell Death Investigation and Therapy (CDIT) Laboratory, Department of Human Structure and Repair, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium. Electronic address: dmitri.krysko@ugent.be.

PMID: 33640304
DOI: 10.1016/j.trecan.2021.01.013

Abstract

Photodynamic therapy (PDT) is widely used in cancer treatment; however, several challenges compromise its efficiency. We propose a synergistic action between PDT and ferroptotic cell death. PDT acts as a source of reactive oxygen species for the Fenton reaction, which may reinforce ferroptosis induction and increase PDT efficacy in anticancer therapy.

Keywords: cancer therapy; ferroptosis; immunogenic cell death; immunotherapy; photosensitizes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carbolines / administration & dosage
Cell Line, Tumor
Chlorophyllides / administration & dosage
Ferroptosis / drug effects*
Humans
Mice
Nanoparticle Drug Delivery System*
Neoplasms / drug therapy*
Photochemotherapy / methods*
Photosensitizing Agents / administration & dosage*
Piperazines / administration & dosage
Reactive Oxygen Species
Sorafenib
Treatment Outcome

Substances

Carbolines
Chlorophyllides
Nanoparticle Drug Delivery System
Photosensitizing Agents
Piperazines
RSL3 compound
Reactive Oxygen Species
erastin
phytochlorin
Sorafenib