Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

Johannes Burtscher; Muhammed Muazzam Kamil Syed; Hilal A Lashuel; Grégoire P Millet

doi:10.1002/mds.28544

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

Mov Disord. 2021 Apr;36(4):857-861. doi: 10.1002/mds.28544. Epub 2021 Feb 27.

Authors

Johannes Burtscher^{1

2}, Muhammed Muazzam Kamil Syed³, Hilal A Lashuel³, Grégoire P Millet²

Affiliations

¹ Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
² Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
³ Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, EPFL, Lausanne, Switzerland.

PMID: 33638916
DOI: 10.1002/mds.28544

Abstract

Several lines of research point to a key role of low oxygen supply (hypoxia) in Parkinson's disease pathogenesis. Although severe hypoxia is detrimental for the brain, physiological adaptations to mild hypoxia are neuroprotective. Herein we discuss, how neuroprotective effects can be induced by hypoxia conditioning and how related approaches have the potential to be harnessed as therapeutic strategies in Parkinson's disease. © 2021 International Parkinson and Movement Disorder Society.

Keywords: conditioning; hypoxia; mitochondria; neurodegeneration; α-synuclein.

MeSH terms

Adaptation, Physiological
Humans
Hypoxia*
Parkinson Disease* / therapy