Hindering triple negative breast cancer progression by targeting endogenous interleukin-30 requires IFNγ signaling

Clin Transl Med. 2021 Feb;11(2):e278. doi: 10.1002/ctm2.278.

Abstract

IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of endogenous IL30, requires INFγ production by T and NK cells.

Keywords: IFNγ; interleukin-30; triple negative breast cancer; tumor microenvironment.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Proliferation / physiology*
  • Disease Models, Animal
  • Disease Progression
  • Interferon-gamma / immunology*
  • Interleukins / immunology*
  • Mice
  • Signal Transduction / immunology*
  • Triple Negative Breast Neoplasms / immunology*
  • Triple Negative Breast Neoplasms / pathology*

Substances

  • Interleukins
  • Interferon-gamma