This investigation examined the effect of rest- redistribution (RR) on the circulating cytokine response to resistance exercise in resistance- trained women. Participants (n = 13; 24 ± 4y; 65.0 ± 10.6 kg; 160.5 ± 5.1 cm) completed two sessions of back squats at 70% of 1- repetition maximum: Traditional sets (TS: 4x10, 120-s inter- set rest) and RR (4x 2x5) with 30-s intra- set rest after 5 repetitions and 90-s inter- set rest. Serum creatine kinase (CK), IL-1β, IL-6, IL-8, IL-10, IL-15, and IL-6/IL-10 were determined before (PRE), immediately- post (IP), and 5, 15, 30, 60 min, 24 h, and 48 h post- exercise. CK increased significantly (p < 0.05) from PRE through 24 h for TS and through 48 h for RR. IL-15 was greater for RR than TS at 48 h. A condition effect was found for IL-10 and IL-6/IL-10 with a lower IL-10 and a greater IL-6/IL-10 for RR. A time effect demonstrated that IL-1β and IL-10 peaked at IP. IL-8 was increased from 5 min to 60 min and 24 h. IL-6/IL-10 was increased from PRE to 30 min, 60 min, and 24 h. These results suggested that rest period configuration- specific differences exist for the inflammatory response in trained women during intramuscular homoeostatic disruption.
Keywords: Inflammatory state; cytokines; interleukins; rest redistribution.