Histopathological Findings Predict Renal Recovery in Severe ANCA-Associated Vasculitis Requiring Intensive Care Treatment

Samy Hakroush; Desiree Tampe; Peter Korsten; Philipp Ströbel; Michael Zeisberg; Björn Tampe

doi:10.3389/fmed.2020.622028

Histopathological Findings Predict Renal Recovery in Severe ANCA-Associated Vasculitis Requiring Intensive Care Treatment

Front Med (Lausanne). 2021 Feb 9:7:622028. doi: 10.3389/fmed.2020.622028. eCollection 2020.

Authors

Samy Hakroush¹, Desiree Tampe², Peter Korsten², Philipp Ströbel¹, Michael Zeisberg^{2

3}, Björn Tampe²

Affiliations

¹ Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
² Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.
³ German Center for Cardiovascular Research (DZHK), Göttingen, Germany.

Abstract

Renal involvement is a common and severe complication of AAV as it can cause ESRD. Histopathological subgrouping and ARRS are helpful to predict long-term ESRD in patients with AAV. Because a subgroup of critically ill patients with severe AAV present with deterioration of kidney function requiring RRT at admission, we here aimed to evaluate histopathological findings and predictive value of Berden's histopathological subgrouping and ARRS for severity of AKI and requirement of RRT during the short-term clinical course in critically ill patients requiring intensive care treatment and predictors for short-term renal recovery in patients requiring RRT. A subgroup of 15/46 (32. 6%) AAV patients with biopsy-proven AAV required RRT during the short-term course of disease, associated with requirement of critical care treatment. While histopathological subgrouping and ARRS were associated with requirement of acute RRT, presence of global glomerular scarring was the strongest predictor of failure to recover from RRT after initiation of remission induction therapy. This new aspect requires further investigation in a prospective controlled setting for therapeutic decision making especially in this subgroup.

Keywords: ANCA-associated vasculitis; acute kidney injury; autoimmune diseases; inflammation; intensive care treatment; renal replacement therapy; systemic vasculitis.