Phytochemical Profiling and Biological Activity of the Australian Carnivorous Plant, Drosera magna

J Nat Prod. 2021 Apr 23;84(4):964-971. doi: 10.1021/acs.jnatprod.0c00869. Epub 2021 Feb 25.

Abstract

Phytochemical profiling was undertaken on the crude extracts of Drosera magna to determine the nature of the chemical constituents present. In total, three new flavonol diglycosides (1-3), one new flavan-3-ol glycoside (4), and 12 previously reported compounds of the flavonol (5, 9), flavan-3-ol (15), flavanone (8), 1,4-napthoquinone (6, 7, 13, 14), 2,3-dehydroxynapthalene-1,4-dione (10-12), and phenolic acid (16) structure classes were isolated and identified. Compounds 1-9, 13, 17, and 18 were assessed for antimicrobial activity, with compounds 6, 7, 8, and 9 showing significant activity. Compounds 1, 2, and 6 were also evaluated for anthelmintic activity against larval forms of Hemonchus contortus, with compound 6 being active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / isolation & purification
  • Anthelmintics / pharmacology*
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology*
  • Carnivorous Plant / chemistry
  • Drosera / chemistry*
  • Flavonoids
  • Flavonols / isolation & purification
  • Flavonols / pharmacology*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Haemonchus / drug effects
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry
  • Plant Roots / chemistry
  • Western Australia

Substances

  • Anthelmintics
  • Anti-Infective Agents
  • Flavonoids
  • Flavonols
  • Glycosides
  • Phytochemicals
  • flavan-3-ol