Association between hepatitis B virus infection and colorectal liver metastasis: a meta-analysis

Rongqiang Liu; Weihao Kong; Mingbin Deng; Guozhen Lin; Tianxing Dai; Linsen Ye

doi:10.1080/21655979.2021.1890871

Association between hepatitis B virus infection and colorectal liver metastasis: a meta-analysis

Bioengineered. 2021 Dec;12(1):736-744. doi: 10.1080/21655979.2021.1890871.

Authors

Rongqiang Liu^{1

2}, Weihao Kong³, Mingbin Deng¹, Guozhen Lin¹, Tianxing Dai¹, Linsen Ye¹

Affiliations

¹ Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
² Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
³ Department of Emergency Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Abstract

The paper aims to assess the association between Hepatitis B Virus infection and colorectal liver metastasis by conducting a meta-analysis. The relevant studies were searched until 24 July 2020, Studies that assessed the correlation between HBV infection and CRLM were recruited. A random effects model was applied to calculate the odds ratio (OR) with 95% confidence interval (CI). All data analyses were performed by STATA 12.0 software. Ten studies involving 17529 participants were included in the study. The results shown that there was obvious association between HBV infection and CRLM (OR: 0.51, 95% CI: 0.28-0.91). The study type and case-control rate may be the main causes of heterogeneity. In addition, HBV infection had no association with extrahepatic metastasis or prognosis of patients with CRLM. Sensitivity analyses confirmed that the results were stable, and Egg's test indicated that there was no publication bias. Patients with HBV infection have the reduced risk of CRLM.

Keywords: Hepatitis B Virus; colorectal liver metastasis; meta-analysis.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Aged
Colorectal Neoplasms* / complications
Colorectal Neoplasms* / epidemiology
Colorectal Neoplasms* / pathology
Female
Hepatitis B* / complications
Hepatitis B* / epidemiology
Humans
Liver Neoplasms* / complications
Liver Neoplasms* / epidemiology
Liver Neoplasms* / secondary
Male
Middle Aged
Odds Ratio
Prognosis

Grants and funding

This work was supported by grants from Guangdong Basic and Applied Basic Research Foundation [2019A1515110654], the Fundamental Research Funds for the Central Universities [20ykpy38], China Postdoctoral Science Foundation [2019TQ0369, 2020M672987]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.