Immune function of miR-214 and its application prospects as molecular marker

Qiuyuan Wang; Yang Liu; Yiru Wu; Jie Wen; Chaolai Man

doi:10.7717/peerj.10924

Immune function of miR-214 and its application prospects as molecular marker

PeerJ. 2021 Feb 16:9:e10924. doi: 10.7717/peerj.10924. eCollection 2021.

Authors

Qiuyuan Wang¹, Yang Liu¹, Yiru Wu¹, Jie Wen¹, Chaolai Man¹

Affiliation

¹ College of Life Science and Technology, Harbin Normal University, Harbin, China.

Abstract

MicroRNAs are a class of evolutionary conserved non-coding small RNAs that play key regulatory roles at the post-transcriptional level. In recent years, studies have shown that miR-214 plays an important role in regulating several biological processes such as cell proliferation and differentiation, tumorigenesis, inflammation and immunity, and it has become a hotspot in the miRNA field. In this review, the regulatory functions of miR-214 in the proliferation, differentiation and functional activities of immune-related cells, such as dendritic cells, T cells and NK cells, were briefly reviewed. Also, the mechanisms of miR-214 involved in tumor immunity, inflammatory regulation and antivirus were discussed. Finally, the value and application prospects of miR-214 as a molecular marker in inflammation and tumor related diseases were analyzed briefly. We hope it can provide reference for further study on the mechanism and application of miR-214.

Keywords: miR-214; Immune cell; Inflammation; Molecular marker; Tumor immunity; Virus.

Grants and funding

This work was supported by the Science Foundation of Heilongjiang Province [grant number LH2019C073], and the Postgraduate Innovation Project of Harbin Normal University [grant number HSDSSCX2020-07]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.