MicroRNA signature in liver cancer

Soudeh Ghafouri-Fard; Kasra Honarmand Tamizkar; Bashdar Mahmud Hussen; Mohammad Taheri

doi:10.1016/j.prp.2021.153369

MicroRNA signature in liver cancer

Pathol Res Pract. 2021 Mar:219:153369. doi: 10.1016/j.prp.2021.153369. Epub 2021 Feb 9.

Authors

Soudeh Ghafouri-Fard¹, Kasra Honarmand Tamizkar¹, Bashdar Mahmud Hussen², Mohammad Taheri³

Affiliations

¹ Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
³ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Mohammad_823@yahoo.com.

PMID: 33626406
DOI: 10.1016/j.prp.2021.153369

Abstract

Liver cancer is the 7^th utmost frequent neoplasm and the 4^th principal source of cancer deaths. This malignancy is linked with several environmental and lifestyle-related factors emphasizing the role of epigenetics in its pathogenesis. MicroRNAs (miRNAs) have been regarded as potent epigenetic mechanisms partaking in the pathogenesis of liver cancer. Dysregulation of miRNAs has been related with poor outcome of patients with liver cancer. In the current manuscript, we provide a concise review of the results of recent studies about the role of miRNAs in the progression of liver cancer and their diagnostic and prognostic utility.

Keywords: Hepatocellular carcinoma; Liver cancer; miRNA.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics*
Carcinoma, Hepatocellular / diagnosis
Carcinoma, Hepatocellular / genetics
Carcinoma, Hepatocellular / metabolism
Carcinoma, Hepatocellular / pathology*
Gene Expression Profiling / methods
Gene Expression Regulation, Neoplastic / genetics*
Humans
Liver Neoplasms / diagnosis
Liver Neoplasms / genetics
Liver Neoplasms / metabolism
Liver Neoplasms / pathology*
Prognosis

Substances

Biomarkers, Tumor