Construction of Pyridine-Based Chiral Ionic Covalent Organic Frameworks as a Heterogeneous Catalyst for Promoting Asymmetric Henry Reactions

Minghui Chen; Jiabin Zhang; Chenxi Liu; Hongrui Li; Hewei Yang; Yaqing Feng; Bao Zhang

doi:10.1021/acs.orglett.1c00175

Construction of Pyridine-Based Chiral Ionic Covalent Organic Frameworks as a Heterogeneous Catalyst for Promoting Asymmetric Henry Reactions

Org Lett. 2021 Mar 5;23(5):1748-1752. doi: 10.1021/acs.orglett.1c00175. Epub 2021 Feb 24.

Authors

Minghui Chen^{1

2}, Jiabin Zhang¹, Chenxi Liu¹, Hongrui Li¹, Hewei Yang¹, Yaqing Feng^{1

2

3}, Bao Zhang^{1

2}

Affiliations

¹ School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China.
² Guangdong Laboratory of Chemistry and Fine Chemical Industry Jieyang Center, Guangdong Province 522000, PR China.
³ Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, PR China.

PMID: 33624498
DOI: 10.1021/acs.orglett.1c00175

Abstract

The difficulties in the separation of products from the reaction mixture and the recovery of the organic cationic ionic liquids (OCILs) catalysts still need to be addressed. Post modification of the pyridine unit in the covalent organic framework (COF) via the formation of pyridinium salts with the chiral bromoacetate led to the chiral ionic COF with OCIL "immobilized", which was utilized as a heterogeneous catalyst for asymmetric Henry reactions with high yield and excellent stereoselectivity.