Abstract
A series of bis-acryl functionalized porphyrins and their corresponding metalloporphyrins (M=Co, Mn) were synthesized and investigated for their antimicrobial properties through MIC screening and bacteria time-kill kinetic studies. The Mn(III) 4-(bis)methylphenyl-substituted-porphyrins showed superior batericidal activities even in the dark with low hemotoxicity and good cytotoxicity profile.
Keywords:
antimicrobial agents; metalloporphyrins; organometallic; porphyrin.
© 2021 Wiley-VCH GmbH.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Cell Survival / drug effects
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Cells, Cultured
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects*
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Hemolysis / drug effects
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Humans
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Kinetics
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Metalloporphyrins / chemical synthesis
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Metalloporphyrins / chemistry
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Metalloporphyrins / pharmacology*
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Molecular Structure
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Staphylococcus aureus / drug effects*
Substances
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Anti-Bacterial Agents
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Metalloporphyrins