Higher Undercarboxylated to Total Osteocalcin Ratio Is Associated With Reduced Physical Function and Increased 15-Year Falls-Related Hospitalizations: The Perth Longitudinal Study of Aging Women

Cassandra Smith; Joshua R Lewis; Marc Sim; Wai H Lim; Ee Mun Lim; Lauren C Blekkenhorst; Tara C Brennan-Speranza; Leon Adams; Elizabeth Byrnes; Gustavo Duque; Itamar Levinger; Richard L Prince

doi:10.1002/jbmr.4208

Higher Undercarboxylated to Total Osteocalcin Ratio Is Associated With Reduced Physical Function and Increased 15-Year Falls-Related Hospitalizations: The Perth Longitudinal Study of Aging Women

J Bone Miner Res. 2021 Mar;36(3):523-530. doi: 10.1002/jbmr.4208. Epub 2020 Dec 3.

Authors

Cassandra Smith^{1

2}, Joshua R Lewis^{3

4

5}, Marc Sim^{3

5}, Wai H Lim^{5

6}, Ee Mun Lim^{7

8}, Lauren C Blekkenhorst^{3

5}, Tara C Brennan-Speranza^{9

10}, Leon Adams^{5

11}, Elizabeth Byrnes⁷, Gustavo Duque^{2

12}, Itamar Levinger^#^{1

2}, Richard L Prince^#⁵

Affiliations

¹ Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia.
² Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St. Albans, Australia.
³ School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
⁴ Centre for Kidney Research, Children's Hospital at Westmead, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
⁵ Medical School, University Western Australia, Perth, Australia.
⁶ Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Australia.
⁷ Department of Clinical Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, Australia.
⁸ Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.
⁹ Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
¹⁰ School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
¹¹ Department of Hepatology, Sir Charles Gairdner Hospital, Nedlands, Australia.
¹² Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, Australia.

^# Contributed equally.

PMID: 33615560
DOI: 10.1002/jbmr.4208

Abstract

Evidence from animal models suggests that undercarboxylated osteocalcin (ucOC) is involved in muscle mass maintenance and strength. In humans, the ucOC to total (t)OC ratio may be related to muscle strength and perhaps physical function and falls risk, but data are limited. We tested the hypothesis that ucOC and ucOC/tOC ratio are associated with muscle function (muscle strength and physical function) in older women and 15-year falls-related hospitalizations. Serum tOC and ucOC were assessed in 1261 older women (mean age 75.2 ± 2.7 years) forming the Perth Longitudinal Study of Aging Women (1998 to 2013). Timed-up-and-go (TUG) and grip strength were assessed at baseline and at 5 years. Falls-related hospitalizations (14.5-year follow-up) were captured by the Hospital Morbidity Data Collection, via the Western Australian Data Linkage System. At baseline, women with higher ucOC/tOC ratio (quartile 4) had slower TUG performance compared with quartile 1 (~0.68 seconds, p < .01). Grip strength and 5-year change of TUG and grip were not different (p > .05) between quartiles. Fear of falling limiting house, outdoor, and combined activities was significantly different across quartiles (p < .05). Higher ucOC/tOC was significantly associated with poorer TUG performance at baseline and 5-year change in performance, increased walking aid use, and fear of falling (all p < .05). Higher ucOC was related to lower grip strength at baseline (p < .05) but not 5-year change in strength. Those with the highest ucOC/tOC had greater falls-related hospitalizations (unadjusted log rank, p = .004) remaining significant after adjusting for key variables (hazard ratio [HR] = 1.31, 95% confidence interval [CI] 1.09-1.57, p = .004). We identified a large proportion of older women with high ucOC/tOC ratio who had reduced physical function, including its long-term decline and increased risk of falls-related hospitalizations. Early identification of women at higher risk can enable prevention and intervention strategies to occur, reducing risk for injurious falls. © 2020 American Society for Bone and Mineral Research (ASBMR)..

Keywords: AGING; BONE-MUSCLE INTERACTIONS; SARCOPENIA; SKELETAL MUSCLE.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Accidental Falls*
Aged
Aging
Australia
Fear*
Female
Hospitalization
Humans
Longitudinal Studies
Osteocalcin

Substances

Osteocalcin