Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

Patricia Klobusiakova; Jiri Mekyska; Lubos Brabenec; Zoltan Galaz; Vojtech Zvoncak; Jan Mucha; Steven Z Rapcsak; Irena Rektorova

doi:10.1016/j.parkreldis.2021.02.012

Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

Parkinsonism Relat Disord. 2021 Mar:84:122-128. doi: 10.1016/j.parkreldis.2021.02.012. Epub 2021 Feb 9.

Authors

Patricia Klobusiakova¹, Jiri Mekyska², Lubos Brabenec³, Zoltan Galaz², Vojtech Zvoncak², Jan Mucha², Steven Z Rapcsak⁴, Irena Rektorova⁵

Affiliations

¹ Applied Neuroscience Research Group, Central European Institute of Technology - CEITEC, Masaryk University, Brno, Czech Republic; Faculty of Medicine, Masaryk University, Brno, Czech Republic; Surgeon General Office of the Slovak Armed Forces, Ružomberok, Slovak Republic.
² Department of Telecommunications, Brno University of Technology, Brno, Czech Republic.
³ Applied Neuroscience Research Group, Central European Institute of Technology - CEITEC, Masaryk University, Brno, Czech Republic.
⁴ Department of Neurology, College of Medicine, University of Arizona, Tucson, USA.
⁵ Applied Neuroscience Research Group, Central European Institute of Technology - CEITEC, Masaryk University, Brno, Czech Republic; First Department of Neurology, Faculty of Medicine and St. Anne's University Hospital, Masaryk University, Brno, Czech Republic. Electronic address: irena.rektorova@ceitec.muni.cz.

PMID: 33609963
DOI: 10.1016/j.parkreldis.2021.02.012

Abstract

Introduction: Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech.

Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed.

Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control.

Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.

Keywords: Acoustic analysis; Hypokinetic dysarthria; Parkinson's disease; Resting-state functional connectivity; Voxel-based morphometry; fMRI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Connectome*
Dysarthria* / diagnosis
Dysarthria* / etiology
Dysarthria* / pathology
Dysarthria* / physiopathology
Female
Gray Matter* / diagnostic imaging
Gray Matter* / pathology
Gray Matter* / physiopathology
Humans
Magnetic Resonance Imaging*
Male
Multimodal Imaging
Nerve Net* / diagnostic imaging
Nerve Net* / pathology
Nerve Net* / physiopathology
Parkinson Disease* / complications
Parkinson Disease* / diagnostic imaging
Parkinson Disease* / pathology
Parkinson Disease* / physiopathology
Speech Acoustics*
Temporal Lobe* / diagnostic imaging
Temporal Lobe* / pathology
Temporal Lobe* / physiopathology