Exposure to parabens and associations with oxidative stress in adults from South China

Abstract

Parabens are widely applied as preservatives in cosmetics, drugs and food. Previous studies suggested that parabens could exhibit potential risks to human health. However, data on human exposure levels and health effects of parabens remain limited, especially in the potential effects on DNA oxidative stress. This study aimed to investigate urinary levels of parabens in adults from South China and explore the relationships between urinary parabens and DNA oxidative stress. Five short chain parabens, including methyl paraben (MeP), ethyl paraben (EtP), n-propyl paraben (PrP), butyl paraben (BuP) and benzyl paraben (BzP), were determined in urine from 319 adults in Shenzhen, China. MeP, EtP and PrP were frequently detected in urine samples (detection frequencies >66.5%), suggesting broad exposure in South China adults. Median concentrations of MeP, EtP, PrP, BuP and BzP were 5.78, 0.39, 0.35, 0.01 and 0.02 μg/L, respectively. A significantly positive correlation was observed between the urinary concentrations of MeP and PrP (p < 0.01), suggesting similar sources for these two chemicals. In addition, participants with alcohol consumption exhibited significantly lower paraben concentrations in urine than those without alcohol drinking (p < 0.05). Significant association was observed between urinary concentrations of parabens and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels (p < 0.01), while no significant dose-response relationship was found (p > 0.05). A potential risk from PrP exposure was found in South China adults.

Keywords: 8-OHdG; Adults; Health risk assessment; Parabens; Urine.