LDL receptors and their role in targeted therapy for glioma: a review

Shreya Pawar; Tejaswi Koneru; Eva McCord; Katyayani Tatiparti; Samaresh Sau; Arun K Iyer

doi:10.1016/j.drudis.2021.02.008

LDL receptors and their role in targeted therapy for glioma: a review

Drug Discov Today. 2021 May;26(5):1212-1225. doi: 10.1016/j.drudis.2021.02.008. Epub 2021 Feb 18.

Authors

Shreya Pawar¹, Tejaswi Koneru², Eva McCord³, Katyayani Tatiparti⁴, Samaresh Sau⁴, Arun K Iyer⁵

Affiliations

¹ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Troy High School, Troy, MI 48098, USA.
² Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Walled Lake Central High School, Commerce Charter Township, MI 48390, USA.
³ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Grosse Pointe South High School, Grosse Pointe Farms, MI 48236, USA.
⁴ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
⁵ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Molecular Imaging Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address: arun.iyer@wayne.edu.

PMID: 33609780
DOI: 10.1016/j.drudis.2021.02.008

Abstract

Gliomas are highly lethal forms of cancers occurring in the brain. Delivering the drugs into the brain is a major challenge to the treatment of gliomas because of the highly selectively permeable blood-brain barrier (BBB). Tapping the potential of receptor-mediated drug delivery systems using targeted nanoparticles (NPs) is a sought-after step forward toward successful glioma treatment. Several receptors are the focus of research for application in drug delivery. Low-density lipoprotein receptors (LDLR) are abundantly expressed in both healthy brains and diseased brains with a disrupted BBB. In this review, we discuss the LDLR and the types of NPs that have been used to target the brain via this receptor.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / pharmacokinetics
Blood-Brain Barrier / metabolism
Brain Neoplasms / drug therapy*
Brain Neoplasms / pathology
Drug Delivery Systems*
Glioma / drug therapy*
Glioma / pathology
Humans
Nanoparticles
Receptors, LDL / metabolism

Substances

Antineoplastic Agents
Receptors, LDL

Grants and funding

R21 CA179652/CA/NCI NIH HHS/United States