RETRACTED: microRNA-6785-5p-loaded human umbilical cord mesenchymal stem cells-derived exosomes suppress angiogenesis and metastasis in gastric cancer via INHBA

Life Sci. 2021 Nov 1:284:119222. doi: 10.1016/j.lfs.2021.119222. Epub 2021 Feb 17.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figs. 1D+F, 2G, 3C, 4C and 6C, which appear to have the same eyebrow shaped phenotype as many other publications tabulated here (https://docs.google.com/spreadsheets/d/149EjFXVxpwkBXYJOnOHb6RhAqT4a2llhj9LM60MBffM/edit#gid=0). The journal requested the corresponding author comment on these concerns and provide the raw data. However the authors were not able to satisfactorily fulfil this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Angiogenesis; Apoptosis; Cytobiology; Gastric cancer; Inhibin subunit beta A; MicroRNA-6785-5p.

Publication types

  • Retracted Publication

MeSH terms

  • Adult
  • Aged
  • Base Sequence
  • Cell Proliferation / genetics
  • Down-Regulation / genetics
  • Exosomes / metabolism*
  • Exosomes / ultrastructure
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Inhibin-beta Subunits / genetics
  • Inhibin-beta Subunits / metabolism*
  • Male
  • Mesenchymal Stem Cells / metabolism*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Middle Aged
  • Neoplasm Metastasis
  • Neovascularization, Pathologic / genetics*
  • Stomach Neoplasms / blood supply*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Umbilical Cord / cytology*
  • Up-Regulation / genetics

Substances

  • MicroRNAs
  • inhibin beta A subunit
  • Inhibin-beta Subunits