A systematic review and meta-analysis of occupational exposures and risk of follicular lymphoma

Michael K Odutola; Geza Benke; Lin Fritschi; Graham G Giles; Marina T van Leeuwen; Claire M Vajdic

doi:10.1016/j.envres.2021.110887

A systematic review and meta-analysis of occupational exposures and risk of follicular lymphoma

Environ Res. 2021 Jun:197:110887. doi: 10.1016/j.envres.2021.110887. Epub 2021 Feb 17.

Authors

Michael K Odutola¹, Geza Benke², Lin Fritschi³, Graham G Giles⁴, Marina T van Leeuwen¹, Claire M Vajdic⁵

Affiliations

¹ Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales, Australia.
² School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
³ School of Public Health, Curtin University, Perth, Western Australia, Australia.
⁴ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health Monash University, Melbourne, Australia.
⁵ Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: claire.vajdic@unsw.edu.au.

PMID: 33607095
DOI: 10.1016/j.envres.2021.110887

Abstract

Background: The etiology of follicular lymphoma (FL), a common non-Hodgkin lymphoma subtype, is largely unknown.

Objective: We performed a systematic review and meta-analysis of observational studies examining the relationship between occupational exposures and FL risk.

Methods: We searched Ovid MEDLINE, Ovid EMBASE, and Web of Science for eligible observational studies examining job titles or occupational exposures prior to January 1, 2020. We performed a narrative synthesis and used random-effects models to generate meta-estimates of relative risk (RR) with 95% confidence intervals (95%CI) for exposures reported by three or more studies.

Results: Fifty-eight studies were eligible. Ten cohort and 37 case-control studies quantified FL risk in relation to any exposure to one or more occupational groups or agents. Eight cohort and 19 case-control studies examined dose-response relationships. We found evidence of a positive association with increasing plasma concentration of dichlorodiphenyldichloroethylene (DDE; meta-RR = 1.51, 95%CI = 0.99, 2.31; I² = 0.0%) and polychlorinated biphenyls (PCBs; meta-RR = 1.47, 95%CI = 0.97, 2.24; I² = 8.6%). We observed a positive association with exposure to any solvent (meta-RR = 1.16, 95%CI = 1.00, 1.34; I² = 0.0%) and chlorinated solvents (meta-RR = 1.35, 95%CI = 1.09, 1.68; I² = 0.0%). Single studies reported a significant positive dose-response association for exposure to any pesticide, hexachlorobenzene, any organophosphate, diazinon, metolachlor, carbaryl, lindane, trichloroethylene, oils/greases, and extremely low-frequency magnetic fields. Job title-only analyses suggested increased risk for medical doctors and spray painters, and decreased risk for bakers and teachers. Overall, studies demonstrated low risk of bias, but most studies examined small numbers of exposed cases.

Conclusions: Current evidence indicates a positive association between FL and occupational exposure to DDE, PCBs, any solvent and chlorinated solvents. Our findings may help guide policies and practices on the safe use of solvents and inform models of lymphomagenesis. Future studies with larger sample sizes and comprehensive quantitative exposure measures may elucidate other avoidable carcinogenic exposures.

Keywords: Follicular lymphoma; Observational; Occupation; Pesticide; Solvent.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Cohort Studies
Humans
Lymphoma, Follicular* / chemically induced
Lymphoma, Follicular* / epidemiology
Lymphoma, Non-Hodgkin* / chemically induced
Lymphoma, Non-Hodgkin* / epidemiology
Occupational Exposure* / adverse effects
Solvents

Substances

Solvents