The plié by DNA-PK: dancing on DNA

Mol Cell. 2021 Feb 18;81(4):644-646. doi: 10.1016/j.molcel.2021.01.025.

Abstract

In this issue of Molecular Cell, Chen et al. (2020) report the structural transition during DNA-dependent activation of DNA-PK, shedding light on the mechanism by which kinase inhibitors and auto-phosphorylation-deficient DNA-PKcs compromise non-homologous end-joining (Chen et al., 2020).

Publication types

  • Comment

MeSH terms

  • DNA / genetics
  • DNA End-Joining Repair
  • DNA-Activated Protein Kinase / genetics
  • DNA-Activated Protein Kinase / metabolism
  • DNA-Binding Proteins* / metabolism
  • Ku Autoantigen / metabolism
  • Nuclear Proteins* / metabolism
  • Phosphorylation

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • DNA
  • DNA-Activated Protein Kinase
  • Ku Autoantigen