Abstract
In this issue of Molecular Cell, Chen et al. (2020) report the structural transition during DNA-dependent activation of DNA-PK, shedding light on the mechanism by which kinase inhibitors and auto-phosphorylation-deficient DNA-PKcs compromise non-homologous end-joining (Chen et al., 2020).
Copyright © 2021 Elsevier Inc. All rights reserved.
MeSH terms
-
DNA / genetics
-
DNA End-Joining Repair
-
DNA-Activated Protein Kinase / genetics
-
DNA-Activated Protein Kinase / metabolism
-
DNA-Binding Proteins* / metabolism
-
Ku Autoantigen / metabolism
-
Nuclear Proteins* / metabolism
-
Phosphorylation
Substances
-
DNA-Binding Proteins
-
Nuclear Proteins
-
DNA
-
DNA-Activated Protein Kinase
-
Ku Autoantigen