Efficacy of salt reduction for managing overactive bladder symptoms: a prospective study in patients with excessive daily salt intake

Sci Rep. 2021 Feb 18;11(1):4046. doi: 10.1038/s41598-021-83725-9.

Abstract

This study aimed to investigate the efficacy of salt intake restriction on overactive bladder (OAB) symptoms in patients with excessive salt intake. Patients received a brochure on nutritional guidance regarding salt intake reduction and received health education every 4 weeks for 12 weeks. Data from overactive bladder symptom score (OABSS) questionnaires and frequency volume charts (FVCs) were evaluated. The daily salt intake was estimated by determining the urinary sodium and creatinine concentrations using spot urine samples. Of the 98 patients included, 71 (72.4%) successfully restricted their daily salt intake after 12 weeks (salt restricted [R] group), while 27 (27.6%) did not (salt non-restricted [N-R] group). The scores to each OABSS question and the resulting total score improved significantly in the R group; however, the individual scores remained unchanged and the total score increased in the N-R group. The FVC data indicated improved voided volumes in the R group as compared to in the N-R group. Ultimately, 17 (23.9%) patients in the R group no longer fulfilled the OAB diagnostic criteria after salt intake reduction. Thus, salt intake reduction improved urinary symptoms in patients with OAB and may be a therapeutic option for OAB in patients with excessive daily salt intakes.

Publication types

  • Clinical Trial

MeSH terms

  • Aged
  • Creatinine / urine
  • Diet, Sodium-Restricted* / methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Sodium / urine
  • Sodium Chloride, Dietary / administration & dosage
  • Sodium Chloride, Dietary / adverse effects*
  • Surveys and Questionnaires
  • Urinary Bladder, Overactive / diet therapy*
  • Urodynamics

Substances

  • Sodium Chloride, Dietary
  • Sodium
  • Creatinine