ABO incompatibility and mild factor VIII deficiency in the neonate: Not too much of a problem but a challenge on ECMO

Anna Hofer; Barbara Prandstetter; Markus Bruckner; Gabriele Leithner

doi:10.1177/0391398821994113

ABO incompatibility and mild factor VIII deficiency in the neonate: Not too much of a problem but a challenge on ECMO

Int J Artif Organs. 2022 Feb;45(2):243-246. doi: 10.1177/0391398821994113. Epub 2021 Feb 18.

Authors

Anna Hofer¹, Barbara Prandstetter¹, Markus Bruckner¹, Gabriele Leithner²

Affiliations

¹ Department of Anaesthesiology and Intensive Care, Kepler Universitätsklinikum, MED CAMPUS III, Linz, Austria.
² Department of Pediatric Cardiology, Kepler Universitätsklinikum, MED Campus IV, Linz, Austria.

PMID: 33596701
DOI: 10.1177/0391398821994113

Abstract

Coagulopathy and bleeding on extracorporeal membrane oxygenation (ECMO) contribute to a worse outcome, and hyperbilirubinemia is an additional threat for newborn babies. We report a case of a newborn boy with congenital diaphragmatic hernia (CDH) associated with ABO incompatibility and an inherited mild hemophilia A. Due to respiratory failure he needed ECMO on his first day of life. During ECMO an exchange transfusion was performed after an extensive hyperbilirubinemia had evolved. Thereafter severe bleeding occurred, and a very low factor VIII level was found causative for that. After factor VIII substitution bleeding was under control and the baby eventually could be weaned from ECMO, underwent corrective surgery, and recovered.

Keywords: ABO incompatibility; ECMO; congenital diaphragmatic hernia; hemophilia A.

Publication types

Case Reports

MeSH terms

Extracorporeal Membrane Oxygenation*
Hemophilia A*
Hernias, Diaphragmatic, Congenital* / complications
Hernias, Diaphragmatic, Congenital* / therapy
Humans
Infant, Newborn
Male
Retrospective Studies