Advanced microscopy technologies enable rapid response to SARS-CoV-2 pandemic

Cell Microbiol. 2021 Jul;23(7):e13319. doi: 10.1111/cmi.13319. Epub 2021 Mar 1.

Abstract

The ongoing SARS-CoV-2 pandemic with over 80 million infections and more than a million deaths worldwide represents the worst global health crisis of the 21th century. Beyond the health crisis, the disruptions caused by the COVID-19 pandemic have serious global socio-economic consequences. It has also placed a significant pressure on the scientific community to understand the virus and its pathophysiology and rapidly provide anti-viral treatments and procedures in order to help the society and stop the virus spread. Here, we outline how advanced microscopy technologies such as high-throughput microscopy and electron microscopy played a major role in rapid response against SARS-CoV-2. General applicability of developed microscopy technologies makes them uniquely positioned to act as the first line of defence against any emerging infection in the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies, Viral / blood
  • Antiviral Agents / pharmacology
  • COVID-19 Drug Treatment*
  • COVID-19 Serological Testing
  • COVID-19 Vaccines
  • COVID-19* / diagnosis
  • COVID-19* / pathology
  • COVID-19* / virology
  • Cryoelectron Microscopy
  • Drug Development
  • High-Throughput Screening Assays
  • Humans
  • Microscopy / methods*
  • Microscopy, Electron
  • Pandemics
  • SARS-CoV-2* / drug effects
  • SARS-CoV-2* / immunology
  • SARS-CoV-2* / physiology
  • SARS-CoV-2* / ultrastructure
  • Virus Replication

Substances

  • Antibodies, Viral
  • Antiviral Agents
  • COVID-19 Vaccines